Papers

From 2024 to 2026

Contextualized phenovectors reveal a Drosophila serotonergic circuit controlling satiety
Sangyu Xu, Xianyuan Zhang, James C. Stewart, Joses Ho, Deepak Choudhury, Zhiping Wang, Adam Claridge-Chang
bioRxiv 2026. doi:10.64898/2026.07.01.735755

Getting over ANOVA: estimation graphics for multi-group comparisons
Zinan Lu, Jonathan Anns, Yishan Mai, Rou Zhang, Kahseng Lian, Nicole MynYi Lee, Shan Hashir, Lucas Wang Zhuoyu, A. Rosa Castillo Gonzalez, Joses Ho, Hyungwon Choi, Sangyu Xu, Adam Claridge-Chang
Nature Methods 2026. doi:10.1038/s41592-026-03187-7

Brief illumination of an optoGPCR elicits prolonged inhibition of Drosophila behavior
Nicole Mynyi Lee, Yishan Mai, Leif Dalberg, Jonathan Charles Anns, Danesha Devini Suresh, Zhiyi Zhang, Adam Claridge-Chang
bioRxiv 2026. doi:10.64898/2026.05.26.727874

Long-Stokes-shift mScarlet3 as a structural marker for two-photon imaging
Sangyu Xu, Xianyuan Zhang, King Yee Cheung, Yishan Mai, Yue Wu, Adam Claridge-Chang
microPublication Biology 2026. doi:10.17912/micropub.biology.002142

A mushroom-body output neuron that mediates octopamine-driven and hunger-motivated feeding in Drosophila
Xianyuan Zhang, Sangyu Xu, Joses Ho, James C. Stewart, Adam Claridge-Chang
bioRxiv 2026. doi:10.64898/2026.03.13.711740

Two-photon characterisation of long-Stokes-shift dye ATTO 490LS for single-laser multicolour imaging
King Yee Cheung, Yue Wu, Shu Ying Lee, Xianyuan Zhang, Masahiro Fukuda, Danesha Devini Suresh, Adam Claridge-Chang
microPublication Biology 2026. doi:10.17912/micropub.biology.001955

The other side of neurotransmission: nomenclature for receptor cells
Adam Claridge-Chang
Zenodo 2026. doi:10.5281/zenodo.18373728

The structure of an actin nucleus stabilized by villin
Robert C. Robinson, Thitipat Chongrungreang, Khongpon Ponlachantra, Bundit Boonyarit, Geoffrey F. Dilly, Yang I. Li, Peter R. Girguis, Richard R. Copley, Adam Claridge-Chang
Science Advances 2025. doi:10.1126/sciadv.adw6915

Stabilized ion selectivity corrects activation drift in kalium channelrhodopsins
Xiao Duan, Chong Zhang, Stanislav Ott, Zhiyi Zhang, Christiane Ruse, Sven Dannhaeuser, Robert Jacobi, Nadine Ehmann, Divya Sachidanandan, Georg Nagel, Manfred Heckmann, Robert Kittel, Alexander Gottschalk, Adam Claridge-Chang, Shiqiang Gao
Advanced Science 2025. doi:10.1002/advs.202509180

Chromosome-scale genome assembly and gene annotation of the hydrothermal vent annelid Alvinella pompejana yield insight into animal evolution in extreme environments
Sami El Hilali, Philippe Dru, Alan Le Moan, Yang I Li, Martijn A. Huynen, André Hoelz, Robert C. Robinson, José M. Martín-Durán, Didier Jollivet, Adam Claridge-Chang, Richard R. Copley
BMC Biology 2025. doi:10.1186/s12915-025-02369-7

Entirely synthetic memory inception via dual optogenetic activation of sensory and dopaminergic neurons
Tayfun Tumkaya, Xianyuan Zhang, Yishan Mai, James Stewart, Adam Claridge-Chang
iScience 2025. doi:10.1016/j.isci.2025.113540

From 2021 to 2024

Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion
Farhan Mohammad, Yishan Mai, Joses Ho, Xianyuan Zhang, Stanislav Ott, James Charles Stewart, Adam Claridge-Chang
PLOS Biology 2024. doi:10.1371/journal.pbio.3002843

Kalium channelrhodopsins effectively inhibit neurons
Stanislav Ott, Sangyu Xu, Nicole Lee, Ivan Hee Kean Hong, Jonathan Anns, Danesha Devini Suresh, Zhiyi Zhang, Xianyuan Zhang, Raihanah Harion, Weiying Vivian Ye, Vaishnavi Chandramouli, Suresh J Jesuthasan, Yasunori Saheki, Adam Claridge-Chang
Nature Communications 2024. doi:10.1038/s41467-024-47203-w

The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila
Tien T. Dang, Yen-Hua Huang, Stanislav Ott, Quentin Kaas, Adam Claridge-Chang, David J. Craik
Journal of Biological Chemistry 2022. doi:10.1016/j.jbc.2022.102413

Genomic patterns of divergence in the early and late steps of speciation of the deep-sea vent thermophilic worms of the genus Alvinella
Camille Thomas–Bulle, Denis Bertrand, Niranjan Nagarajan, Richard Copley, Erwan Corre, Stéphane Hourdez, Éric Bonnivard, Adam Claridge-Chang, Didier Jollivet
BMC Ecology and Evolution 2022. doi:10.1186/s12862-022-02057-y

Most primary olfactory neurons have individually neutral effects on behavior
Tayfun Tumkaya, Safwan Burhanudin, Asghar Khalilnezhad, James Stewart, Hyungwon Choi, Adam Claridge-Chang
eLife 2022. doi:10.7554/eLife.71238

Contingent stimulus delivery assay for zebrafish reveals a role for CCSER1 in alcohol preference
Fatima Megala Nathan, Caroline Kibat, Tanisha Goel, James Stewart, Adam Claridge-Chang, Ajay S Mathuru
Addiction Biology 2022. doi:10.1111/adb.13126

Dengue virus infection modifies mosquito blood-feeding behavior to increase transmission to the host
Benjamin Wong Wei Xiang, Wilfried A. A. Saron, James Charles Stewart, Arthur Hain, Varsha Walvekar, Dorothée Missé, Fréderic Thomas, R. Manjunatha Kini, Benjamin Roche, Adam Claridge-Chang, Ashley L. St John, Julien Pompon
PNAS 2022. doi:10.1073/pnas.2117589119

Research raises fresh questions on adverse impact of ‘long Covid’. Here’s why a vaccine-plus approach is needed
Adam Claridge-Chang
TODAY 2022. link

Clearing the air on Covid-19 transmission
Adam Claridge-Chang
The Straits Times 2022. link

Characterization of seizure induction methods in Drosophila
Jurga Mituzaite, Rasmus Petersen, Adam Claridge-Chang, Richard A. Baines
eNeuro 2021. doi:10.1523/ENEURO.0079-21.2021

A neural m6A/YTHDF pathway is required for learning and memory in Drosophila
Lijuan Kan, Stanislav Ott, Brian Joseph, Eun Sil Park, Crystal Dai, Ralph Kleiner, Adam Claridge-Chang, Eric C. Lai
Nature Communications 2021. doi:10.1038/s41467-021-21537-1

China’s ‘zero Covid’ vs Singapore’s ‘living with it’: rapid low-cost testing could mean we don’t need to choose
Adam Claridge-Chang
South China Morning Post 2021. link

From 2015 to 2020

Neurons that function within an integrator to promote a persistent behavioral state in Drosophila
Yonil Jung, Ann Kennedy, Hui Chiu, Farhan Mohammad, Adam Claridge-Chang, David J. Anderson
Neuron 2020. doi:10.1016/j.neuron.2019.10.028

Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy
Holger Hengel et al.
Nature Communications 2020. doi:10.1038/s41467-020-14360-7

Moving beyond P values: data analysis with estimation graphics
Joses Ho, Tayfun Tumkaya, Sameer Aryal, Hyungwon Choi, Adam Claridge-Chang
Nature Methods 2019. doi:10.1038/s41592-019-0470-3

Learning a spatial task by trial and error in Drosophila
Ulrich Stern, Hemant Srivastava, Hsueh-Ling Chen, Farhan Mohammad, Adam Claridge-Chang, Chung-Hui Yang
Current Biology 2019. doi:10.1016/j.cub.2019.06.045

Fully automated leg tracking of Drosophila neurodegeneration models reveals distinct conserved movement signatures
Shuang Wu, Kah Junn Tan, Lakshmi Narasimhan Govindarajan, James Charles Stewart, Lin Gu, Joses Wei Hao Ho, Malvika Katarya, Boon Hui Wong, Eng-King Tan, Daiqin Li, Adam Claridge-Chang, Camilo David Libedinsky, Li Cheng, Sherry Shiying Aw
PLOS Biology 2019. doi:10.1371/journal.pbio.3000346

Optogenetic olfactory behavior depends on illumination characteristics
Tayfun Tumkaya, James Stewart, Safwan Burhanudin, Adam Claridge-Chang
bioRxiv 2019. doi:10.1101/559674

Motor context coordinates visually guided walking in Drosophila
Tomás Cruz, Terufumi Fujiwara, Nélia Varela, Farhan Mohammad, Adam Claridge-Chang, M Eugenia Chiappe
bioRxiv 2019. doi:10.1101/572792

Using Drosophila behavioral assays to characterize terebrid venom-peptide bioactivity
Anders Eriksson, Prachi Anand, Juliette Gorson, Corina Grijuc, Elina Hadelia, James Stewart, Mandë Holford, Adam Claridge-Chang
Scientific Reports 2018. doi:10.1038/s41598-018-33215-2

A systematic review of Drosophila short-term-memory genetics: meta-analysis reveals robust reproducibility
Tayfun Tumkaya, Stanislav Ott, Adam Claridge-Chang
Neuroscience & Biobehavioral Reviews 2018. doi:10.1016/j.neubiorev.2018.07.016

The Drosophila microbiome has a limited influence on sleep, activity, and courtship behaviors
Joel Selkrig, Farhan Mohammad, Soon Hwee Ng, Jia Yi Chua, Tayfun Tumkaya, Joses Ho, Yin Ning Chiang, Dirk Rieger, Sven Pettersson, Charlotte Helfrich-Foerster, Joanne Yew, Adam Claridge-Chang
Scientific Reports 2018. doi:10.1038/s41598-018-28764-5

A zinc-finger fusion protein refines Gal4-defined neural circuits
Shamprasad Varija Raghu, Farhan Mohammad, Jia Yi Chua, Claudia Barros, Joanne Lam, Mavis Loberas, Sadhna Sahani, Adam Claridge-Chang
Molecular Brain 2018. doi:10.1186/s13041-018-0390-7

Optical inhibition of zebrafish behavior with anion channelrhodopsins
Gadisti Aisha Mohamed, Ruey-Kuang Cheng, Joses Ho, Seetha Krishnan, Farhan Mohammad, Adam Claridge-Chang, Suresh Jesuthasan
BMC Biology 2017. doi:10.1186/s12915-017-0430-2

Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism
Anders Eriksson, Marlena Raczkowska, Rapeechai Navawongse, Deepak Choudhury, James Stewart, Yi Ling Tang, Zhiping Wang, Adam Claridge-Chang
Scientific Reports 2017. doi:10.1038/s41598-017-08466-0

Optogenetic inhibition of behavior with anion channelrhodopsins
Farhan Mohammad, James Stewart, Stanislav Ott, Katarina Chlebikova, Jia Yi Chua, Tong-Wey Koh, Joses Ho, Adam Claridge-Chang
Nature Methods 2017. doi:10.1038/nmeth.4148

Lie-X: depth image based articulated object pose estimation, tracking, and action recognition on Lie groups
Chi Xu, Lakshmi Narasimhan Govindarajan, Yu Zhang, James Stewart, Zoë Bichler, Suresh Jesuthasan, Adam Claridge-Chang, Ajay Sriram Mathuru, Wenlong Tang, Peixin Zhu, Li Cheng
International Journal of Computer Vision 2017. doi:10.1007/s11263-017-0998-6

Concordance and incongruence in preclinical anxiety models: systematic review and meta-analyses
Farhan Mohammad, Joses Ho, Chun Lei Lim, Jia Hern Woo, Dennis Jun Jie Poon, Bhumika Lamba, Adam Claridge-Chang
Neuroscience & Biobehavioral Reviews 2016. doi:10.1016/j.neubiorev.2016.04.011

Ancient anxiety pathways influence Drosophila defense behaviors
Farhan Mohammad, Sameer Aryal, Joses Ho, James Charles Stewart, Nurul Ayuni Norman, Tan Teng Li, Agnese Eisaka, Adam Claridge-Chang
Current Biology 2016. doi:10.1016/j.cub.2016.02.031

Drosophila learn efficient paths to a food source
Rapeechai Navawongse, Deepak Choudhury, Marlena Raczkowska, James Charles Stewart, Terrence Lim, Mashiur Rahman, Alicia Guek Geok Toh, Zhiping Wang, Adam Claridge-Chang
Neurobiology of Learning and Memory 2016. doi:10.1016/j.nlm.2016.03.019

Estimation statistics should replace significance testing
Adam Claridge-Chang, Pryseley N. Assam
Nature Methods 2016. doi:10.1038/nmeth.3729

From 2010 to 2015

Mouse pose estimation from depth images
Ashwin Nanjappa, Li Cheng, Wei Gao, Chi Xu, Adam Claridge-Chang, Zoe Bichler
arXiv 2015. link

Estimating information processing through a memory system: the utility of meta-analytic methods for genetics
Tugce Yildizoglu, Jan-Marek Weislogel, Farhan Mohammad, Edwin S.-Y. Chan, Pryseley N. Assam, Adam Claridge-Chang
PLOS Genetics 2015. doi:10.1371/journal.pgen.1005718

The right dorsal habenula limits attraction to an odor in zebrafish
Seetha Krishnan, Ajay S. Mathuru, Caroline Kibat, Mashiur Rahman, Charlotte Lupton, James Stewart, Adam Claridge-Chang, Shih-Chen Yen, Suresh Jesuthasan
Current Biology 2014. doi:10.1016/j.cub.2014.03.073

Why countries need to invest more in research
Adam Claridge-Chang
TODAY 2014. link

Estimation statistics
Adam Claridge-Chang
Wikipedia 2013. link

The surveillance state of behavioral automation
Andreas T. Schaefer, Adam Claridge-Chang
Current Opinion in Neurobiology 2012. doi:10.1016/j.conb.2011.11.004

Before lab formation, to 2009

Writing memories with light-addressable reinforcement circuitry
Adam Claridge-Chang, Robert Roorda, Eleftheria Vrontou, Lucas Sjulson, Haiyan Li, Jay Hirsh, Gero Miesenböck
Cell 2009. doi:10.1016/j.cell.2009.11.010

Excitatory local circuits and their implications for olfactory processing in the fly antennal lobe
Yuhua Shang, Adam Claridge-Chang, Lucas Sjulson, Marc Pypaert, Gero Miesenböck
Cell 2007. doi:10.1016/j.cell.2006.12.034

Control of daily transcript oscillations in Drosophila by light and the circadian clock
Herman Wijnen, Felix Naef, Catherine Boothroyd, Adam Claridge-Chang, Michael W. Young
PLOS Genetics 2006. doi:10.1371/journal.pgen.0020039

Circadian regulation of gene expression systems in the Drosophila head
Adam Claridge-Chang, Herman Wijnen, Felix Naef, Catherine Boothroyd, Nikolaus Rajewsky, Michael W. Young
Neuron 2002. doi:10.1016/S0896-6273(01)00515-3

Molecular genetics of timing in intrinsic circadian rhythm sleep disorders
Herman Wijnen, Catherine Boothroyd, Michael W Young, Adam Claridge-Chang
Annals of Medicine 2002. doi:10.1080/078538902320772133