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About the Lab
What
The mission of the lab is to develop and use neurogenetics methods to better understand basic brain functions that are disrupted in common mental disorders. The lab has technical expertise in genetics, behavior, data analysis, instrumentation development, optogenetics, neuroanatomy, and related methods. We are interested in associative learning, feeding, synaptic function, and related behaviors, including the role of conserved genes involved in these processes that will help us understand human brain function and dysfunction.
Where
Since 2011 the lab has been in the Neuroscience and Behavioral Disorders Program at Duke-NUS Medical School. From 2012 to 2021, the lab was located at the Institute of Molecular and Cell Biology. From 2011 to 2013 the lab was part of the Neuroscience Research Partnership at A*STAR. Before that, 2008–2010 the lab was at the Wellcome Trust Centre for Human Genetics, University of Oxford.
Who
We are an international group of scientists with experience in neurogenetics, molecular biology, sensory neuroscience and research engineering. More here. We collaborate with bioinformaticians, marine biologists, engineers, structural biologists, statisticians and other neuroscientists here in Singapore and abroad. If you are interested in joining us there is more information here.
Why Drosophila?
For a century, the vinegar fly Drosophila melanogaster has been the dominant animal genetic system, having been used to elucidate the pathways involved in body formation (development). In the past 50 years, this fly has also emerged as an important experimental system for the study of brain and behavior. The small, genetically-tractable vinegar fly brain is helping scientists understand the ‘mezzanine’ problem of neuroscience: how the connectivity and activity patterns of neurons and circuits can generate behavior, including those from which fundamental cognitive and emotional processes emerge.